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KMID : 0043319850080040205
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Archives of Pharmacal Research
1985 Volume.8 No. 4 p.205 ~ p.211
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The Penetration Site of Local Anesthetics into Liposomal Membrane
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Han SK
Bae SJ/Yun I/Kim NH
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Abstract
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The distribution of local anesthetics between the hydrocarbon interior and surface area of the lipid bilayer of liposomal membrane was calculated employing fluorescence probe technique. The quenching of fluorescence of 12-(9-anthroyl) stearic acid and N-octadecyl naphthyl-2-amine-6-sulfonic acid by the local anesthetics in liposomal system was used to calculate the distribution. The Stern-Volmer equation was modified and employed for this calculation. The results showed that procaine hydrochloride and benzocaine were mainly distributed on the surface area of the lipid bilayer of the liposomal membrane, while tetracaine hydrochloride penetrated effectively into the hydrocarbon interior and showed even distribution in the lipid bilayer.
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